NOT KNOWN FACTUAL STATEMENTS ABOUT PKRRATING

The interfacial residues are highly conserved among eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements exhibit which the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations guidance a model exactly where activating RNA serves like a scaffold to bind a number of PKR monomers, ri

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